Publications

KP and Advisors:

KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis
Kevin S. Harris, William Brabant, Sheila Styrchak, Alexander Gall, Richard Daifuku
Antiviral Research 67 (March 2005) 1-9

Lethal Mutagenesis of HIV
Robert A. Smith, Lawrence A. Loeb, Bradley D. Preston
Virus Research 107 (2005) 215-228

Mechanistic studies on KP-1212
Eisuke Murakami, Aravind Basavapathruni, William Bradley, and Karen S. Anderson
Department of Pharmacology, Yale University School of Medicine

Viral Error Catastrophe By Mutagenic Nucleosides
Jon P. Anderson, Richard Daifuku, and Lawrence A. Loeb
Annu. Rev. Microbiol. 2004. 58:183–205

Stealth Nucleosides
Richard Daifuku, Koronis Pharmaceuticals (2003)

Lethal mutagenesis of HIV with mutagenic nucleoside analogs
Lawrence A. Loeb, John M. Essigmann, Farhad Kazazi, Jue Zhang, Karl D. Rose and James I. Mullins
Proc. Natl. Acad. Sci. USA, Vol. 96, pp. 1492–1497, February 1999

Other Relevant Publications:

Therapeutically targeting RNA viruses via lethal mutagensis
Jason D Graci and Craig E Cameron, Future Virology, 2008

Examining the Theory of Error Catastrophe
Jesse Summers and Samuel Litwin
Journal of Virology, Jan. 2006, p.20-26

Viral Quasispecies
Manfred Eigen, Scintific American, July 1993